Let me just say that I can't wait for Snow Leopard (the next version of Mac OS X).  I'm looking forward to the increased stability and performance promised by the Steve.  I'm especially interested in better multi-proc support as I'm constantly in and out of a Windows VM and I'm hoping that activity will be a little more smooth on a faster host OS.

I generally find Leopard to be very stable and haven't had too many issues but I do occasionally run into issues with the Bluetooth device not responding.  Intermittently the menu bar icon just says "Bluetooth Not Available".  It seems mostly to happen after connecting or disconnecting certain USB devices to the machine.

After hunting for a solution I came across this Apple support document.  It seems like a bit heavy handed, and I'm not exactly sure why: "Over time, the settings in the System Management Controller may become unusable, which can result in operational anomalies with the computer."

However, it solved my problem and I'm once again mousing away with my fantastic Microsoft Bluetooth Notebook Mouse 500, which I highly recommend for the heavy laptop user like myself.